The Path Substitutions tab allows you to specify how file paths can be modified to account for copying a build from a build machine to a development machine or test machine.
File paths need to be modified otherwise the debug information will point to source code in locations that don't exist on the new machine.
There are no substitutions set up by default:

Path Substitutions
Or you may just be copying a build from a drive on a development machine to a subdirectory on a drive on your test machine.
•Add 
 adds a row to the File Paths Substitutions table 
 enter the new path that will replace the old path in the New Path column 
 click in the Old Path column 
 enter the path that is being replaced 
For example, you might enter c:\users\stephen\documents for the new path and f:\dev\build for the old path.
You can double click to edit drives and paths in the table, or remove items:
•Remove 
 removes selected substitutions from the list 
•Remove All 
 removes all substitutions from the list 
Alternatively, press 
 to delete selected items, and 
 + 
 to select all items in the list first.
Example: Changed disk drive
Project originally located at  | 
m:\dev\build\testApp  | 
Project copied to  | 
e:\dev\build\testApp  | 
New Path  | 
e:\  | 
Old Path  | 
m:\  | 
Example: Project copied to a new location
Project originally located at  | 
f:\dev\build\testApp  | 
Project copied to  | 
C:\Users\Stephen\Documents\testApp  | 
New Path  | 
C:\Users\Stephen\Documents  | 
Old Path  | 
f:\dev\build  | 
 The slashes do not have to match, a forward slash will match a backslash when comparing path fragments. This is deliberate - to improve ease of use with libraries built by different compilers (LLVM and compilers that use it use forward slashes, whereas Visual Studio etc use backslashes).
Path substitution can be turned off, use only manually specified paths, perform automatic path substitution based on best guesses based on information in the executable, or a combination.
Use the combo box to choose the appropriate path substitution method. The default is automatic path substitution and if that fails to try path substitution using the manually specified paths.
•No path substitution 
 path substitution does not happen 
•Only substitute specified paths 
 path substitution uses the manually specified paths 
•Automatic substitution only 
 path substitution is performed automatically using information in the executable 
•Automatic substitution, specified paths if substitution fails 
 an attempt at automatic path substitution is made, if this fails path substitution is performed using the manually specified paths 
The default is Automatic substitution, specified paths if substitution fails.
Reset All - Resets all global settings, not just those on the current page.
Reset - Resets the settings on the current page.